Table 3 Average evolutionary conservation of amino acid residues important for SOD1 structure and function
| Residue list | Mean evolutionary conservations of residues from list | Significance of difference from mean evolutionary conservation over all protein residues |
|---|---|---|
| All residues | −1.3*10−5 (≈0) | – |
| Residues forming destructive hydrogen bonds | 0.3 | 0.05 |
| Residues with increased mechanical stiffness to copper | 0.57 | 8.1*10−4 |
| Residues with top mean stiffness to all residues | 0.64 | 0.013 |